Die DGHM prämiert Veröffentlichungen, die sich durch eine große Anwendungsrelevanz auszeichnen. Für diese Auszeichnung können Publikationen vorgschlagen werden, an denen ein DGHM-Mitglied als Erst- oder LetztautorIn beteiligt ist und die in den vorangegangenen 3 Monaten hochrangig publiziert wurden.
Aktuelles Highlight der Infektionsprävention und Klin. Mikrobiologie
The transmission risk of multidrug-resistant organisms between hospital patients and their pets – a case-control study, Germany, 2019 to 2022
Carolin Hackmann1 , Antonia Genath1 , Désirée Gruhl1 , Anna Weber1 , Friederike Maechler1 , Axel Kola1 , Frank Schwab1 , Stefan Schwarz 2,3 , Antina Lübke-Becker2,3 , Thomas Schneider4 , Petra Gastmeier1 , Rasmus Leistner1,4
Carolin Hackmann
Euro Surveill. 2024 Sep;29(39)
Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/39328155/
Abstract:
Background: Carriage of multidrug-resistant organisms (MDROs) in humans constitutes an important public health concern. Cross-transmission of bacteria between animals and humans has been demonstrated before.
Aim: Our aim was to quantify the risk factor ‚pet ownership‘ for MDRO colonisation in hospital patients.
Methods: We performed a matched case-control study from 2019 to 2022 in Berlin, Germany and compared MDRO-positive and MDRO-negative patients in terms of contact with pets and other risk factors for MDRO acquisition. Patients completed a questionnaire-based interview and provided nasal and rectal swabs. Pet owners provided swab samples from the throat and stool of their pets (dogs and cats). Phenotypically matching samples of owners and pets were analysed via whole genome sequencing.ResultsThe analyses included 2,891 patients. Reported pet ownership was 17.7% in MDRO-positives (154/871) and 23.4% in MDRO-negatives (472/2,020). Among 397 owner-pet pairs, we identified one pair sharing genotypically indistinguishable pathogens (0.3%). A risk factor analysis of pet ownership was performed for carriers of meticillin-resistant Staphylococcus aureus (MRSA) (OR = 0.662; 95% CI: 0.343-1.277), vancomycin-resistant enterococci (VRE) (OR = 0.764; 95% CI: 0.522-1.118) and multidrug-resistant Gram-negative bacteria (MDR-GNB) (OR = 0.819; 95% CI: 0.620-1.082). Colonisation with MDRO was rare in pets, and dogs were more often colonised than cats (MRSA: 0% vs 0%, VRE: 1.5% vs 1.0%, MDR-GNB: 17.2% vs 3.6%).
Conclusion: Transmission of MDROs between humans and pets is possible though rare. In an urban living space, neither cat nor dog ownership appears as a relevant risk factor for MDRO carriage in hospital patients.
Kommentar:
Haustiere und ihre Besitzer teilen dieselbe Umgebung und leben in engem Kontakt miteinander. Eine Kolonisation mit multiresistenten Erregern (MRE), d. h. ein symptomfreies Vorhandensein bestimmter Bakterien z. B. im Darm oder auf der Haut, kann sowohl beim Menschen als auch bei Haustieren auftreten. Die Ergebnisse unserer Studie haben gezeigt, dass eine MRE-Übertragung zwischen Krankenhauspatientinnen und -patienten und ihren Haustieren möglich, aber extrem selten ist. Die Erkenntnisse aus unserer Studie werden dazu beitragen, die Identifizierung von Patienten mit hohem Risiko für eine MRE-Kolonisation und die empirische antimikrobielle Behandlungsstrategie bei Krankenhauspatientinnen und -patienten weiter zu verbessern. Nach unseren Ergebnissen stellt Haustierbesitz keinen relevanten Risikofaktor für eine MRE-Kolonisation bei Krankenhausaufnahme dar. Dennoch sollte die Übertragung zwischen Besitzenden und Haustieren im Auge behalten werden, insbesondere bei Patientinnen und Patienten mit rezidivierenden Infektionen oder persistierender Kolonisation. Unsere Studie fördert die Anwendung des One-Health-Ansatzes, insbesondere im Bereich der antimikrobiellen Resistenz.
Kontakt:
Dr. Carolin Hackmann
Robert Koch-Institut
13353 Berlin
hackmannc@rki.de
Autor:inneninformationen:
1 Institute of Hygiene and Environmental Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany.
2 Institute of Microbiology and Epizootics, School of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
3 Veterinary Centre of Resistance Research (TZR), School of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
4 Division of Gastroenterology, Infectious Diseases and Rheumatology, Medical Department, Charité – Universitätsmedizin Berlin, Berlin, Germany.
Frühere Highlights
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Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/37823667/
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Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/37271195/
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Link zum voständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/35435751/
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Candidates
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(*are joint first authors)
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Link zum vollständigen Artikel: pubmed.ncbi.nlm.nih.gov/33285279/
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Link zum vollständigen Artikel: pubmed.ncbi.nlm.nih.gov/33298160/